11-3-52B Multi-susceptible, Chronic Fatigue Risk, Avoid Gardasil Consideration

An 11-3-52B haplotype is linked to increased sensitivity to multiple biotoxins. Individuals with this haplotype may have a harder time clearing certain toxins from the body because their immune system may not recognize them properly in order to tag and remove from the body. This haplotype has also been linked in some research to a higher likelihood of developing Chronic Fatigue Syndrome (CFS). 

Biotoxins may include (not limited to):



  • Mold
  • Actinobacteria
  • Endotoxins (from Gram-negative bacteria)
  • Cyanobacteria (from blue-green algae)
  • Dinoflagellates (toxic plankton)
  • Pfisteria (algae-related toxin)
  • Ciguatera (toxin from reef fish)
  • Lyme
  • Brown recluse spider venom
  • Rattlesnake venom
What this means:
This haplotype has been referred to as one of the “dreaded genes”. While progress can be slower, people with this genetic profile can respond just as well to treatment as those with other haplotypes.

Chronic Fatigue Risk:
There is also a reported link to increased susceptibility to Chronic Fatigue Syndrome (CFS). This does not mean you will develop CFS — it simply suggests a genetic predisposition that might make you more sensitive to prolonged fatigue following biotoxin exposure.

Gardasil Consideration:
It is suggested that individuals with this haplotype may want to avoid the Gardasil vaccine (used for HPV) due to anecdotal concerns. Please consult a trusted healthcare provider before making any medical decisions.





** Your HLA genes are part of your immune system’s ability to recognize and respond to threats. But certain haplotypes are essentially “faulty”—they don’t help your body recognize or clear biotoxins the way most people’s do. This sets off the innate immune response, which triggers inflammation, but the adaptive immune system never kicks in to finish the job. The result? Toxins get trapped in the body, inflammation floods your system, and the immune response never shuts off. This is what can lead to CIRS—Chronic Inflammatory Response Syndrome. *This information is for educational purposes only and not a substitute for medical care. **