understanding HLA haplotypes
Understanding haplotypes is a key part of healing from mold and CIRS.
4-3-53 (Multisusceptible / Chronic Fatigue)
The 4-3-53 haplotype is one of the better-studied gene patterns linked to increased sensitivity to multiple biotoxins. Individuals with this haplotype may have a harder time clearing biotoxins toxins from the body because their immune system may not recognize them properly. This haplotype has also been linked in some research to a higher likelihood of developing Chronic Fatigue Syndrome (CFS).
This haplotype has been connected to increased reactivity to a variety of biotoxin sources, including:
This haplotype has been connected to increased reactivity to a variety of biotoxin sources, including:
- Mold
- Actinobacteria
- Endotoxins (from Gram-negative bacteria)
- Cyanobacteria (from blue-green algae)
- Dinoflagellates (toxic plankton)
- Pfisteria (algae-related toxin)
- Ciguatera (toxin from reef fish)
- Lyme
- Brown recluse spider venom
- Rattlesnake venom
Because of its broad reactivity, this gene type is sometimes referred to as one of the “dreaded” haplotypes — but let me be clear, people with this haplotype still respond well to treatment when given the right support and protocols.
** Your HLA genes are part of your immune system’s ability to recognize and respond to threats. But certain haplotypes are essentially “faulty”—they don’t help your body recognize or clear biotoxins the way most people’s do. This sets off the innate immune response, which triggers inflammation, but the adaptive immune system never kicks in to finish the job. The result? Toxins get trapped in the body, inflammation floods your system, and the immune response never shuts off. This is what can lead to CIRS—Chronic Inflammatory Response Syndrome. *This information is for educational purposes only and not a substitute for medical care. **
