understanding HLA haplotypes
Understanding haplotypes is a key part of healing from mold and CIRS.
7-3-53 (Mold Susceptible)
A 7-3-53 haplotype may have a harder time recognizing and eliminating mold-related toxins. While this doesn’t confirm mold exposure, it does suggest a possible genetic predisposition to struggle with clearing toxins when exposure happens.
What this means:
The 7-3-53 haplotype has been associated with increased biotoxin sensitivity specific to mold. That means your immune system may not respond as effectively when exposed to mold in places like water-damaged buildings or humid environments.
A quick note:
Carrying this haplotype doesn't mean you have mold illness or are currently being exposed — it simply points to how your body may process mold biotoxins differently than others.
What this means:
The 7-3-53 haplotype has been associated with increased biotoxin sensitivity specific to mold. That means your immune system may not respond as effectively when exposed to mold in places like water-damaged buildings or humid environments.
A quick note:
Carrying this haplotype doesn't mean you have mold illness or are currently being exposed — it simply points to how your body may process mold biotoxins differently than others.
** Your HLA genes are part of your immune system’s ability to recognize and respond to threats. But certain haplotypes are essentially “faulty”—they don’t help your body recognize or clear biotoxins the way most people’s do. This sets off the innate immune response, which triggers inflammation, but the adaptive immune system never kicks in to finish the job. The result? Toxins get trapped in the body, inflammation floods your system, and the immune response never shuts off. This is what can lead to CIRS—Chronic Inflammatory Response Syndrome. *This information is for educational purposes only and not a substitute for medical care. **
