understanding HLA haplotypes
Understanding haplotypes is a key part of healing from mold and CIRS.
4-7-53 (Multisusceptible)
The 4-7-53 haplotype is another pattern commonly associated with multisusceptibility to biotoxins — meaning the immune system may struggle to recognize and clear certain toxins effectively.
Individuals with this genetic type may be more reactive to several biotoxin sources, such as:
Individuals with this genetic type may be more reactive to several biotoxin sources, such as:
- Mold
- Actinobacteria
- Endotoxins (from Gram-negative bacteria)
- Cyanobacteria (from blue-green algae)
- Dinoflagellates (toxic plankton)
- Pfisteria (algae-related toxin)
- Ciguatera (toxin from reef fish)
- Lyme
- Brown recluse spider venom
- Rattlesnake venom
It’s not unusual for people with this haplotype to feel like they’re “sensitive to everything.” In fact, this gene pattern is sometimes referred to as one of the “dreaded” haplotypes — but I want to be clear: this nickname doesn’t reflect your true healing potential.
Having a multisusceptible haplotype doesn’t mean you can’t get better. It just means we need a more customized, informed approach that honors your body’s unique immune response.
Having a multisusceptible haplotype doesn’t mean you can’t get better. It just means we need a more customized, informed approach that honors your body’s unique immune response.
** Your HLA genes are part of your immune system’s ability to recognize and respond to threats. But certain haplotypes are essentially “faulty”—they don’t help your body recognize or clear biotoxins the way most people’s do. This sets off the innate immune response, which triggers inflammation, but the adaptive immune system never kicks in to finish the job. The result? Toxins get trapped in the body, inflammation floods your system, and the immune response never shuts off. This is what can lead to CIRS—Chronic Inflammatory Response Syndrome. *This information is for educational purposes only and not a substitute for medical care. **
