understanding HLA haplotypes
Understanding haplotypes is a key part of healing from mold and CIRS.
15-6-51 Post-Lyme, MS, Narcolepsy
The 15-6-51 haplotype has been statistically linked to an increased risk of persistent or chronic Lyme disease, particularly following a known exposure (like a tick bite). This susceptibility is thought to relate to how the immune system processes biotoxins produced by Borrelia bacteria.
Transmission:
Tick bites (main vector – Ixodes species)
Other biting insects (fleas, mosquitoes, mites, horseflies – possible but less common)
Maternal–fetal transmission (in utero)
Why It Matters:
Having this haplotype doesn’t mean you currently have Lyme disease—it simply indicates that if you are exposed, your body may be less equipped to fully eliminate the infection, increasing the risk of chronic symptoms. Traditional antibiotic treatment is typically not enough to clear these biotoxins therefore leading to chronic lyme.
Transmission:
Tick bites (main vector – Ixodes species)
Other biting insects (fleas, mosquitoes, mites, horseflies – possible but less common)
Maternal–fetal transmission (in utero)
Why It Matters:
Having this haplotype doesn’t mean you currently have Lyme disease—it simply indicates that if you are exposed, your body may be less equipped to fully eliminate the infection, increasing the risk of chronic symptoms. Traditional antibiotic treatment is typically not enough to clear these biotoxins therefore leading to chronic lyme.
** Your HLA genes are part of your immune system’s ability to recognize and respond to threats. But certain haplotypes are essentially “faulty”—they don’t help your body recognize or clear biotoxins the way most people’s do. This sets off the innate immune response, which triggers inflammation, but the adaptive immune system never kicks in to finish the job. The result? Toxins get trapped in the body, inflammation floods your system, and the immune response never shuts off. This is what can lead to CIRS—Chronic Inflammatory Response Syndrome. *This information is for educational purposes only and not a substitute for medical care. **
