16-5-51 Post-Lyme Syndrome Susceptibility

The 16-5-51 haplotype is statistically associated with a greater likelihood of developing persistent or chronic Lyme disease, particularly after exposure to a tick bite or another transmission of Borrelia bacteria.

Transmission:
Tick bites, other biting insects (fleas, mosquitoes, mites, horseflies – possible but less common), maternal–fetal transmission (in utero)

What This Means:
Carrying this haplotype does not mean you currently have Lyme disease. Instead, it suggests your immune system may have a harder time clearing Lyme-related biotoxins, making you more susceptible to lingering symptoms after infection.

Why It’s Important
Understanding this haplotype can help explain why some individuals develop Post-Lyme Syndrome or chronic fatigue-like symptoms even after treatment. It's not about being broken—it’s about having unique immune system wiring that may require a different support strategy.

If you've experienced ongoing symptoms after a Lyme diagnosis—or suspect exposure—this genetic insight could be a key piece of your healing roadmap. 







** Your HLA genes are part of your immune system’s ability to recognize and respond to threats. But certain haplotypes are essentially “faulty”—they don’t help your body recognize or clear biotoxins the way most people’s do. This sets off the innate immune response, which triggers inflammation, but the adaptive immune system never kicks in to finish the job. The result? Toxins get trapped in the body, inflammation floods your system, and the immune response never shuts off. This is what can lead to CIRS—Chronic Inflammatory Response Syndrome. *This information is for educational purposes only and not a substitute for medical care. **