understanding HLA haplotypes
Understanding haplotypes is a key part of healing from mold and CIRS.
7-2-53 (Mold Susceptible)
If you carry the 7-2-53 haplotype, your body may have a more difficult time recognizing and clearing mold-related toxins. This means your immune system may respond differently if exposure occurs.
What this means:
This haplotype has been associated with increased susceptibility to biotoxins produced by mold, especially when mold is present in indoor environments (like water-damaged buildings). Your body may not be as efficient at identifying or eliminating these toxins, which can trigger or prolong symptoms of Chronic Inflammatory Response Syndrome (CIRS).
Important clarification:
Having this haplotype doesn’t mean mold or mycotoxins are currently in your body — it only points to how your immune system might react if exposure happens.
Disease Risk:
What this means:
This haplotype has been associated with increased susceptibility to biotoxins produced by mold, especially when mold is present in indoor environments (like water-damaged buildings). Your body may not be as efficient at identifying or eliminating these toxins, which can trigger or prolong symptoms of Chronic Inflammatory Response Syndrome (CIRS).
Important clarification:
Having this haplotype doesn’t mean mold or mycotoxins are currently in your body — it only points to how your immune system might react if exposure happens.
Disease Risk:
- People with this haplotype may have an increased risk of developing Celiac Disease.
** Your HLA genes are part of your immune system’s ability to recognize and respond to threats. But certain haplotypes are essentially “faulty”—they don’t help your body recognize or clear biotoxins the way most people’s do. This sets off the innate immune response, which triggers inflammation, but the adaptive immune system never kicks in to finish the job. The result? Toxins get trapped in the body, inflammation floods your system, and the immune response never shuts off. This is what can lead to CIRS—Chronic Inflammatory Response Syndrome. *This information is for educational purposes only and not a substitute for medical care. **
