understanding HLA haplotypes
Understanding haplotypes is a key part of healing from mold and CIRS.
14-5-52B Multisusceptible
Individuals with this haplotype may have a harder time clearing certain toxins from the body because their immune system may not recognize them properly. 14-5-52B is genetically associated with increased sensitivity to a broad range of biotoxins, including:
- Mold
- Actinobacteria
- Endotoxins (from Gram-negative bacteria)
- Cyanobacteria (from blue-green algae)
- Dinoflagellates (toxic plankton)
- Pfisteria (algae-related toxin)
- Ciguatera (toxin from reef fish)
- Lyme
- Brown recluse spider venom
- Rattlesnake venom
What This Means for You:
People with this haplotype may have a harder time identifying and clearing biotoxins due to the way their immune system responds to these threats.
This haplotype has sometimes been referred to as one of the "dreaded" genes—but that label is not to be discouraging. Many individuals with this genotype respond very well to treatment once a proper diagnosis and protocol are in place.
Why It Matters:
Knowing this about your genetics doesn’t predict illness—but it does offer important insight into your body’s detox and immune pathways. And with the right support, healing is entirely possible.
People with this haplotype may have a harder time identifying and clearing biotoxins due to the way their immune system responds to these threats.
This haplotype has sometimes been referred to as one of the "dreaded" genes—but that label is not to be discouraging. Many individuals with this genotype respond very well to treatment once a proper diagnosis and protocol are in place.
Why It Matters:
Knowing this about your genetics doesn’t predict illness—but it does offer important insight into your body’s detox and immune pathways. And with the right support, healing is entirely possible.
** Your HLA genes are part of your immune system’s ability to recognize and respond to threats. But certain haplotypes are essentially “faulty”—they don’t help your body recognize or clear biotoxins the way most people’s do. This sets off the innate immune response, which triggers inflammation, but the adaptive immune system never kicks in to finish the job. The result? Toxins get trapped in the body, inflammation floods your system, and the immune response never shuts off. This is what can lead to CIRS—Chronic Inflammatory Response Syndrome. *This information is for educational purposes only and not a substitute for medical care. **
