understanding HLA haplotypes
Understanding haplotypes is a key part of healing from mold and CIRS.
4-8-53 (Multisusceptible)
The 4-8-53 haplotype is part of the multisusceptible group — a pattern that may make it harder for the immune system to recognize and eliminate certain types of biotoxins. This means that individuals with this haplotype may have an increased sensitivity to a range of environmental and microbial exposures.
Biotoxins commonly linked to this haplotype include:
Biotoxins commonly linked to this haplotype include:
- Mold
- Actinobacteria
- Endotoxins (from Gram-negative bacteria)
- Cyanobacteria (from blue-green algae)
- Dinoflagellates (toxic plankton)
- Pfisteria (algae-related toxin)
- Ciguatera (toxin from reef fish)
- Lyme
- Brown recluse spider venom
- Rattlesnake venom
This gene pattern, like other multisusceptible types, has been casually referred to as a "dreaded" haplotype, but I want to be clear — that nickname is outdated and unhelpful. You are not doomed by your genetics. Recovery is absolutely possible with the right approach.
Healing is available — even with a multisusceptible haplotype. We just need to support your immune system in a way that works for your unique biology.
Healing is available — even with a multisusceptible haplotype. We just need to support your immune system in a way that works for your unique biology.
** Your HLA genes are part of your immune system’s ability to recognize and respond to threats. But certain haplotypes are essentially “faulty”—they don’t help your body recognize or clear biotoxins the way most people’s do. This sets off the innate immune response, which triggers inflammation, but the adaptive immune system never kicks in to finish the job. The result? Toxins get trapped in the body, inflammation floods your system, and the immune response never shuts off. This is what can lead to CIRS—Chronic Inflammatory Response Syndrome. *This information is for educational purposes only and not a substitute for medical care. **
